I've been having an increasing amount of itching on my right shin since last year and made the connection of taking a higher quality gummy vitamin from Smarty Pants. I bought 4 bottles and took about a half dose each day while skipping some days. I've really had no luck with any multi vitamins anyways, so I'll just give them up for a while. Honestly, I think most supplements are wasteful, except when a person is truly deficient in something. Also, lab created vitamins don't act the same in the body as natural foods do, since they have the full spectrum of nutrients and the body's enzymes acting on them.